کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1985198 1539957 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inflammatory signalling as mediator of epigenetic modulation in tissue-specific chronic inflammation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Inflammatory signalling as mediator of epigenetic modulation in tissue-specific chronic inflammation
چکیده انگلیسی

Recent successes of therapeutic intervention in chronic inflammatory diseases using epigenetic modifiers such as histone deacetylase inhibitors and inhibitors of DNA methylation suggest that epigenetic reprogramming plays a role in the aetiology of these diseases. The epigenetic signature of a given immune cell is reflected in the history of modifications from different signals the cell has been subjected to during differentiation. Like other cells, differentiating immune cells are dependent on a complex combination of inter- and intracell signalling as well as transcription machineries to modulate their epigenomes in order to mediate differentiation. Despite extensive research into these processes, the link between cellular signalling and epigenetic modulation remains poorly understood. Here, we review recent progress and discuss key factors driving epigenetic modulation in chronic inflammation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 41, Issue 1, January 2009, Pages 176–184
نویسندگان
, , ,