کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1985607 1540229 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structure and antioxidative property of a polysaccharide from an ammonium oxalate extract of Phellinus linteus
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Structure and antioxidative property of a polysaccharide from an ammonium oxalate extract of Phellinus linteus
چکیده انگلیسی


• A novel polysaccharide (PL-A11) purified from acidic extract of P. linteus mycelia.
• PL-A11 was a neutral heteropolysaccharide with an Mw of 13.8 kDa.
• The structural feature of PL-A11 was elucidated by physical and chemical analyses.
• PL-A11 exhibited potential antioxidant activities in vivo.
• PL-A11 could be developed as a functional food or therapeutic agent.

In this paper, the novel polysaccharide PL-A11 was purified from an ammonium oxalate extract of Phellinus linteus mycelia. Its physicochemical properties, structural characteristics, and antioxidant activities were investigated. Results showed that PL-A11 had a weight-average molecular weight (Mw) of 13.8 kDa and was mainly composed of arabinose, xylose, mannose, and glucose in a molar ratio of 1.1:1.3:1.0:6.6. The backbone of PL-A11 was composed of (1 → 4)-α-d-glucopyranosyl, (1 → 2)-α-d-xylopyranosyl, and (1 → 3)-α-d-arabinofuranosyl residues, whereas the (1 → 6)-α-d-mannopyranosyl residues formed branches at the O-2 position with 1-linked-α-d-glucopyranosyl terminal residues. From the antioxidative activity tests in vivo, the administration of PL-A11 obviously enhanced the activity of antioxidant enzymes and significantly reduced the level of malondiadehyde (MDA) in the serum and liver of d-galactose-treated aging mice in a dose-dependent manner, as well as effectively stimulated the immune system of aging mice. These findings implied that PL-A11 could be developed as a potential antioxidant for applications in the functional food, pharmaceutical, cosmetic or nutraceutical industries.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 91, October 2016, Pages 92–99
نویسندگان
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