Optimization of aceclofenac-loaded pectinate-poly(vinyl pyrrolidone) beads by response surface methodology

The paper describes development of aceclofenac-loaded pectinate-poly(vinyl pyrrolidone) [PVP] beads through ionotropic-gelation. Effects of amount of pectin and PVP on drug encapsulation efficiency (DEE), and cumulative drug release at 6 h (R6h) were optimized by using response surface methodology. The optimized beads showed DEE of 96.58 ± 4.15% and R6h of 41.62 ± 2.18% with controlled drug release pattern. FTIR spectroscopy analysis revealed possible intermolecular hydrogen bonding, which could be formed between CO groups of PVP and OH groups of pectin in these beads. The swelling of these beads were influenced by pH of the medium.