کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1987316 | 1540298 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro antiherpetic and antirotaviral activities of a sulfate prepared from Mimosa scabrella galactomannan
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
A chemically sulfated galactomannan (BRS) from seeds of Mimosa scabrella had in vitro antiviral activity against Herpes simplex virus 1 (HSV-1), but not against Simian rotavirus A/SA11 (SiRV-A/SA11). It was examined by 13C NMR spectroscopy, which showed the sulfate groups to be mainly at C-6 of galactose residues. BRS had a selective inhibition against HSV-1 during its attachment step, having an IC50 lower than 2.5 μg/ml, determined by plaque reduction, and a selectivity index of greater than 181, suggesting that the antiviral effect is likely due to interactions between the virus and BRS, being influenced its overall surface charge.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 45, Issue 5, 1 December 2009, Pages 453-457
Journal: International Journal of Biological Macromolecules - Volume 45, Issue 5, 1 December 2009, Pages 453-457
نویسندگان
Francielli Chrestani, Maria Rita Sierakowski, Daniel Esdras de Andrade Uchoa, Carlos Nozawa, Guilherme Lanzi Sassaki, Philip Albert James Gorin, Lucy Ono,