کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1987459 | 1540288 | 2010 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Alginate-based ferrofluid and magnetic microsphere thereof Alginate-based ferrofluid and magnetic microsphere thereof](/preview/png/1987459.png)
The Fe3O4 ferrofluids have been prepared using sodium alginate (Na–AL) as a stabilizing agent. The alginate can prevent the aggregation of magnetic nanoparticles and hence contributed to higher stability for the ferrofluids. Furthermore, the alginate component in the ferrofluids was crosslinked by Ca2+ to produce magnetic microspheres. The swelling behavior of magnetic microspheres showed a pH-dependence, and hence determined the drug release process under various pH conditions. The presence of the Fe3O4 nanoparticles made the magnetic microspheres swell more easily. Meanwhile, the strong ability to absorb the drug for the incorporated Fe3O4 nanoparticles decreased the release rate and hence was more favorable to the sustaining release of drug. Except for the controlled delivery and release of drug, the alginate-based ferrofluids and magnetic microspheres in this work might also show a great potential for other biomedical and biotechnological applications, such as, magnetic targeting, magnetic separation and magnetic resonance imaging.
Journal: International Journal of Biological Macromolecules - Volume 47, Issue 5, 1 December 2010, Pages 654–660