کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1987652 1540308 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural analysis of point mutations in the Hairless gene and their association with the activity of the Hairless protein
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Structural analysis of point mutations in the Hairless gene and their association with the activity of the Hairless protein
چکیده انگلیسی

The Notch signaling pathway (NSP) is an important intercellular communication mechanism that regulates embryo development and adult physiological functions. The Hairless (H) protein is a powerful antagonist of the NSP by its interaction with the Suppressor of Hairless (Su[H]) protein, recruiting the corepressors Gro and CtBP. In the present work, we examined the role of several important amino acids in different H protein domains analyzing four mutant lines of Drosophila melanogaster. The mutant alleles were evaluated by single-strand conformational polymorphism (SSCP) analysis and we located mutated regions at different positions along the sequence of the Hairless gene.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 43, Issue 5, 1 December 2008, Pages 426–432
نویسندگان
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