کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1987652 | 1540308 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structural analysis of point mutations in the Hairless gene and their association with the activity of the Hairless protein
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
The Notch signaling pathway (NSP) is an important intercellular communication mechanism that regulates embryo development and adult physiological functions. The Hairless (H) protein is a powerful antagonist of the NSP by its interaction with the Suppressor of Hairless (Su[H]) protein, recruiting the corepressors Gro and CtBP. In the present work, we examined the role of several important amino acids in different H protein domains analyzing four mutant lines of Drosophila melanogaster. The mutant alleles were evaluated by single-strand conformational polymorphism (SSCP) analysis and we located mutated regions at different positions along the sequence of the Hairless gene.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 43, Issue 5, 1 December 2008, Pages 426–432
Journal: International Journal of Biological Macromolecules - Volume 43, Issue 5, 1 December 2008, Pages 426–432
نویسندگان
Daniel Paz-Gómez, Víctor Manuel Baizabal-Aguirre, Juan José Valdez-Alarcón, Marcos Cajero-Juárez, Anja C. Nagel, Anette Preiss, Dieter Maier, Alejandro Bravo-Patiño,