کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1987732 | 1540310 | 2008 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Isolation, purification and antitumor activity of lipopolysaccharide from cow placenta Isolation, purification and antitumor activity of lipopolysaccharide from cow placenta](/preview/png/1987732.png)
Lipopolysaccharide from cow placenta (LPS-CP-2) has been isolated and purified by hot phenol–water extraction, enzyme hydrolysis, chloroform–petroleum ether method, ion-exchange and gel-filtration chromatography. Also, LPS-PS-2 was evaluated for antitumor activity against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. LPS-PS-2 caused significant (P < 0.05) decrease in tumor volume, and viable cell count; and it prolonged the life span of EAC-tumor-bearing mice. Hematological profile indicates that LPS-CP-2 possessed protective action on the haemopoietic system. Further, administration of LPS-CP-2 reduced the tumor volume of both DLA and EAC cell lines in a dose-dependent way. The LPS-PS was found to be devoid of pyrogenic response in the rabbits. These results indicate that LPS-PS exhibited significant antitumor activity without pyrogenic response, suggesting its potential as antitumor agent.
Journal: International Journal of Biological Macromolecules - Volume 43, Issue 3, 1 October 2008, Pages 232–237