کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1988820 | 1540457 | 2014 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immunohistochemical mapping of pro-opiomelanocortin- and pro-dynorphin-derived peptides in the alpaca (Lama pacos) diencephalon
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کلمات کلیدی
SNRLHbIIIVPMPVHsupraoptic hypothalamic nucleusVMHVPLlateroposterior thalamic nucleusOPTSNCventroanterior thalamic nucleusPVASTHSPFMHb - MHBSubstantia Nigra, pars reticulata - Substantia Nigra، pars reticulataSCH - اس اسstria medullaris - استریا مدولاریBeta-endorphin - بتا آندورفینthird ventricle - بطن سومThalamus - تالاموسsubstantia nigra, pars compacta - توده سیاه، پارس متراکمmammillothalamic tract - دستگاه ماملیوتالاموسoptic tract - دستگاه نوریfornix - فورنیکسArc - قوسLeucine-enkephalin - لوسین-انکافالینmedian eminence - مدرنیتهzona incerta - منطقه نامشخصlateral hypothalamic area - منطقه هیپوتالاموس جانبیanterior hypothalamic area - منطقه هیپوتالاموس قدامیdorsal hypothalamic area - منطقه ی هیپوتالاموس پشتیanteromedial thalamic nucleus - هسته تالام مفاصلrhomboid thalamic nucleus - هسته تالاموس رامبوییcentral medial thalamic nucleus - هسته تالاموم مرکز مرکزیlaterodorsal thalamic nucleus - هسته تالامیک laterodorsalMediodorsal thalamic nucleus - هسته تالامیک Medidorsalreuniens thalamic nucleus - هسته تالامیک reuniensventrolateral thalamic nucleus - هسته تالامیک ventrolateralanterodorsal thalamic nucleus - هسته تالامیک بیحرکتیreticular thalamic nucleus - هسته تالامیک رتیکالsubparafascicular thalamic nucleus - هسته تالامیک زیرباساسیکیکولرcentrolateral thalamic nucleus - هسته تالامیک مرکزیventromedial thalamic nucleus - هسته تالامیک ونتومدیالparacentral thalamic nucleus - هسته تالامیک پارازنده ایParaventricular thalamic nucleus - هسته تالامیک پاراوتری استLateral mammillary nucleus - هسته جانبی ماملیال جانبیLateral habenular nucleus - هسته حنجره جانبیmedial habenular nucleus - هسته عصب مرکزیarcuate nucleus - هسته قوسMedial mammillary nucleus - هسته ماملیاری MedialVentromedial hypothalamic nucleus - هسته هیپوتالاموس VentromedialPosterior hypothalamic nucleus - هسته هیپوتالاموس عقبparaventricular hypothalamic nucleus - هسته هیپوتالاموس پروژستیکlateral geniculate nucleus - هسته ژنیکول جانبی جانبیanteroventral thalamic nucleus - هسته ی تالامیک یونیورواستاتیکSubthalamic nucleus - هسته ی زیرهالامیکSuprachiasmatic nucleus - هستههای سوپراکیاسماتیکadrenocorticotropin hormone - هورمون adrenocorticotropinalpha-melanocyte-stimulating hormone - هورمون تحریک کننده آلفا ملانوستیHypothalamus - هیپوتالاموسoptic chiasm - چیماس اپتیکیcapsula interna - کپسول داخلی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Using an indirect immunoperoxidase technique, we studied the distribution of cell bodies and fibres containing non-opioid peptides (adrenocorticotropin hormone (ACTH), alpha-melanocyte-stimulating hormone) and opioid peptides (beta-endorphin (1-27), alpha-neo-endorphin, leucine-enkephalin) in the alpaca diencephalon. No immunoreactive cell bodies containing ACTH were found. Perikarya containing the other four peptides were observed exclusively in the hypothalamus and their distribution was restricted. Perikarya containing alpha-melanocyte-stimulating hormone or alpha-neo-endorphin showed a more widespread distribution than those containing leucine-enkephalin or beta-endorphin (1-27). Cell bodies containing pro-opiomelanocortin-derived peptides were observed in the arcuate nucleus, anterior and lateral hypothalamic areas and in the ventromedial and supraoptic hypothalamic nuclei, whereas perikarya containing alpha-neo-endorphin (a pro-dynorphin-derived peptide) were found in the arcuate nucleus, dorsal and lateral hypothalamic areas, and in the paraventricular, ventromedial and supraoptic hypothalamic nuclei. Immunoreactive cell bodies containing leucine-enkephalin were found in the lateral hypothalamic area and in the paraventricular hypothalamic nucleus. Immunoreactive fibres expressing pro-opiomelanocortin-derived peptides were more numerous than those expressing pro-dynorphin-derived peptides. A close anatomical relationship was observed: in all the diencephalic nuclei in which beta-endorphin (1-27)-immunoreactive fibres were found, fibres containing alpha-melanocyte-stimulating hormone or alpha-neo-endorphin were also observed. Fibres containing beta-endorphin (1-27), alpha-melanocyte-stimulating hormone or alpha-neo-endorphin were widely distributed throughout the diencephalon, but fibres containing ACTH or leucine-enkephalin showed a moderate distribution. The distribution of the five peptides studied here is also compared with that reported previously in other mammalian species. The widespread distribution observed indicates that both the pro-dynorphin and the pro-opiomelanocortin systems are involved in multiple physiological actions (e.g., food intake, thermoregulation, neuroendocrine and reproductive mechanisms) in the alpaca diencephalon.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chemical Neuroanatomy - Volumes 59â60, September 2014, Pages 36-50
Journal: Journal of Chemical Neuroanatomy - Volumes 59â60, September 2014, Pages 36-50
نویسندگان
B. Manso, M.L. Sánchez, L.E. Medina, L.A. Aguilar, Z. DÃaz-Cabiale, J.A. Narváez, R. Coveñas,