کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1990266 1540729 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of fatty acids in the development and progression of nonalcoholic fatty liver disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The role of fatty acids in the development and progression of nonalcoholic fatty liver disease
چکیده انگلیسی

Nonalcoholic fatty liver disease (NAFLD) has emerged as a serious obesity-related disorder. NAFLD encompasses a wide spectrum of hepatic derangements ranging from a surfeit of fat in the liver (steatosis) to lipid surplus accompanied by fibrosis and cellular death (nonalcoholic steatohepatitis or NASH). The most widely accepted model to explain the progression from simple NAFLD to NASH is the “two-hit hypothesis,” wherein fat over accumulation per se is not sufficient to induce the progression to statohepatitis, but renders the liver more susceptible to “second hits” that, once imposed upon the steatotic liver, cause further aberrations that culminate in the development of NASH. However, in light of recent data from our laboratory and elsewhere, we propose that an increased ratio of saturated-to-unsaturated fatty acids delivered to or stored within the liver may, in part, mediate the progression from simple steatosis to NASH. The molecular mechanisms that mediate the effect of saturated fatty acids are unclear, although proinflammatory cytokines, reactive oxygen species, and endoplasmic reticulum stress may all play a role. Collectively, these data suggest that saturated fatty acids may represent an intrinsic second hit to the liver that hastens the development of NASH.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 19, Issue 9, September 2008, Pages 567–576
نویسندگان
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