Attenuation of glomerular filtration barrier damage in adriamycin-induced nephropathic rats with bufalin: An antiproteinuric agent

► Bufalin or prednisone effects on the ADR rats. ► The decrease of proteinuria with bufalin treatment occurred earlier than prednisone. ► Bufalin has advantages in optimising the level of serum TC and TG. ► Ultrastructurally, the foot process effacement and fusion of podocytes were improved. ► The anti-proteinuric mechanism: attenuate the glomerular filtration barrier damage.