کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1991703 1541020 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Breaking through a roadblock in prostate cancer research: An update on human model systems
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Breaking through a roadblock in prostate cancer research: An update on human model systems
چکیده انگلیسی

Prostate cancer is a prevalent disease that affects the aging male population. Whilst there have been significant advances of our biological understanding of the disease, clinical translation of promising agents continues to lag behind. In part, this is due to a paucity of relevant experimental and pre-clinical models required to further develop effective prevention and therapeutic strategies. Genetically modified cell lines fail to entirely represent the genetic and molecular diversity of primary human specimens, particularly from localised disease. Furthermore, primary prostate cancer tissues are extremely difficult to grow in the laboratory and virtually all human models, whether they grow as xenografts in immune-deficient animals or as cell cultures, are genetically modified by the investigator or derived from patients with advanced metastatic disease. In this review, we discuss the latest advances and improvements to current methods of xenografting human primary prostate cancer, and their potential application to translational research.This article is part of a Special Issue entitled ‘Steroids and cancer’.

Figure optionsDownload as PowerPoint slideHighlights
► Clinical translation of new treatments for prostate cancer are required.
► Such advances rely on relevant experimental models.
► Xenografting human prostate cancer specimens in mice has proven to be difficult.
► We discuss the latest advances to prostate cancer xenografting methods.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Steroid Biochemistry and Molecular Biology - Volume 131, Issues 3–5, September 2012, Pages 122–131
نویسندگان
, , , , ,