کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1991780 | 1541036 | 2011 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Alterations of folliculogenesis in women with polycystic ovary syndrome Alterations of folliculogenesis in women with polycystic ovary syndrome](/preview/png/1991780.png)
The objective of the present study was to examine some factors involved in follicular development of women with polycystic ovary syndrome (PCOS). Women with PCOS showed increased levels of serum luteinizing hormone (LH) but decreased follicular production of progesterone and estradiol by pre-ovulatory follicles. The mRNA expression corresponding to steroidogenic acute regulatory protein (StAR), and 20alpha-hydroxysteroid dehydrogenase (20α-HSD) was increased, while that corresponding to cytochrome P450 aromatase (P450arom) was decreased in PCOS follicles as compared to controls. No changes in the mRNA expression for 3beta-hydroxysteroid dehydrogenase 2 (3β-HSD2), cytochrome P450 side-chain cleavage (P450scc), cytochrome P450 17 alpha hydroxylase/lyase (P450c17), cyclooxygenase 2 (COX2), and transcription factors (GATA-4 and GATA-6) were found. We conclude that despite the hyper-luteinized environment of PCOS follicles, these follicles produce lower levels of progesterone and estradiol, and that this is characterized by increased degradation of progesterone and decreased estradiol synthesis. Our data demonstrate that the synthesis of prostaglandin F2α (PGF2α) may be affected in PCOS-follicles and that the transcription factors GATA-4 and GATA-6 are present in PCOS-follicles but they are not involved in the abnormal transcription observed in the steroidogenic enzymes.
Research highlights
► Follicular steroidogenesis and progesterone/estradiol are decreased in women with PCOS in spite of increased serum levels of LH.
► Although transcriptional factors GATA-4 and GATA-6 are present in PCOS and normal follicles, they are not involved in the regulation of steroidogenesis.
► Prostaglandin F2 alpha is decreased in PCOS follicles which downregulates cytochrome P450 aromatase (P450arom) responsible for estradiol synthesis.
Journal: The Journal of Steroid Biochemistry and Molecular Biology - Volume 124, Issues 1–2, March 2011, Pages 58–64