کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1992291 1541077 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of D327N sex hormone-binding globulin gene polymorphism in the pathogenesis of polycystic ovary syndrome
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Role of D327N sex hormone-binding globulin gene polymorphism in the pathogenesis of polycystic ovary syndrome
چکیده انگلیسی

SHBG (sex hormone-binding globulin) is a transport protein specific for dihydrotestosterone, testosterone and estradiol. The missense mutation in exon 8 (GAC → AAC) causing the amino acid exchange Asp → Asn in codon 327 (D327N) correlates according to the published data with increased SHBG levels. We studied possible association of this polymorphism with polycystic ovary syndrome (PCOS) and anthropometric and biochemical parameters in 248 PCOS patients and 109 healthy control women. The D327N polymorphism (wild-type and variant allele) was detected using PCR-RFLP method (restriction enzyme Bbs-I). For statistical evaluation χ2 test, Mann–Whitney test, ANCOVA, ANOVA (NCSS 2004, Statgraphics Plus v.5.1, USA) were used. There was no significant difference in genotype distribution between PCOS and controls (χ2 = 1.03, p = 0.59). Moreover, we did not find an association of the variant allele with plasma SHBG level, steroid hormones, or screened parameters of lipid and glucose metabolism. In conclusion, the D327N polymorphism of the SHBG gene does not influence susceptibility to PCOS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Steroid Biochemistry and Molecular Biology - Volume 104, Issues 1–2, April 2007, Pages 68–74
نویسندگان
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