Pharmacokinetic study of a new testosterone-in-adhesive matrix patch applied every 2 days to hypogonadal men

The present study assessed pharmacokinetic testosterone time profile and dose proportionality after application of a new matrix testosterone patch (30, 45, and 60 cm2 containing 0.5 mg of testosterone per cm2).This open study was a single dose, three-period, crossover trial with a randomised treatment sequence in 24 hypogonadal men, consisting in a single 48-h application of two patches of 2× 30 cm2, 2× 45 cm2, 2× 60 cm2, separated by a 5-day wash-out. Testosterone concentrations were determined during patch application and after patch removal. Dose proportionality was assessed on baseline corrected, dose normalised parameters for Cav,corr/D, Cmax,corr/D and AUC(0–48),corr/D.Testosterone concentrations rose during the first 9 h following patch application, remained relatively sustained until 48 h and then decreased abruptly after patch removal, with a half-life of 1.3 h. Testosterone levels were maintained above 3 ng/mL for 42–45 h with all patches. Cav were 3.39, 4.03 and 4.58 ng/mL and Cmax were 4.33, 5.29 and 6.18 ng/mL according to the doses. AUC(0–48), Cav and Cmax were dose dependent with mean ratios within the acceptance range (0.70–1.43).In conclusion, dose linearity was demonstrated between the different strengths of testosterone patches. Application resulted in dose proportional increases in serum T levels in hypogonadal men into the low to mid-normal range within the first hours and achieved steady state for 48 h. During this short term study with three consecutive patch applications, this patch was shown to be efficient, convenient and safe with excellent adhesiveness and skin tolerability, and with no cross-contamination to partner or to environment.