کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1994469 1064787 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thermosensitive and mucoadhesive delivery systems of mucosal vaccines
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Thermosensitive and mucoadhesive delivery systems of mucosal vaccines
چکیده انگلیسی

Mucosal vaccination is emerging as a potential administration route for eliciting antigen-specific mucosal and systemic immunogenicity. Most mucosal vaccines have been administered in a phosphate-buffered saline vehicle that may limit the exposure of antigens to the mucosal surfaces and result in poor immunogenicity. To improve the potency of the mucosal vaccines, we have developed mucosal vaccine delivery systems that might prevent leakage and increase retention of vaccines on mucosal surfaces. Thermosensitive polymers have been used to reduce the leakage problems of nasal or vaginal vaccines, while mucoadhesive polymers have been employed to increase the mucosal contact of the vaccines. Here, we describe the formulation and delivery methods of mucosal vaccines using thermosensitive and mucoadhesive polymers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Methods - Volume 38, Issue 2, February 2006, Pages 106–111
نویسندگان
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