کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1994653 1541276 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-inflammatory and angiogenic activity of polysaccharide extract obtained from Tibetan kefir
ترجمه فارسی عنوان
فعالیت ضد التهابی و آنژیوژنیک عصاره پلی ساکارید حاصل از کبد تبت
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• We isolate polysaccharides from Tibetan Kefir obtained from whey fermentation.
• The polysaccharides showed angiogenic and anti-inflammatory effect.
• Tibetan Kefir polysaccharides have no cytotoxic effect on VERO cells.
• These findings suggest a possible use of kefir polysaccharide as topical medicine.

The search for new bioactive molecules is a driving force for research pharmaceutical industries, especially those molecules obtained from fermentation. The molecules possessing angiogenic and anti-inflammatory attributes have attracted attention and are the focus of this study. Angiogenic activity from kefir polysaccharide extract, via chorioallantoic membrane assay, exhibited a pro-angiogenic effect compared with vascular endothelial factor (pro-angiogenic) and hydrocortisone (anti-angiogenic) activity as standards with an EC50 of 192 ng/mL. In terms of anti-inflammatory activity determined via hyaluronidase enzyme assay, kefir polysaccharide extract inhibited the enzyme with a minimal activity of 2.08 mg/mL and a maximum activity of 2.57 mg/mL. For pharmaceutical purposes, kefir polysaccharide extract is considered to be safe because it does not inhibit VERO cells in cytotoxicity assays.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microvascular Research - Volume 108, November 2016, Pages 29–33
نویسندگان
, , , , , ,