Estradiol receptors agonists induced effects in rat intestinal microcirculation during sepsis

► Protective effects of estradiol hormone on the splanchnic circulation and the endothelial function. ► Estradiol exerts its biological effects by interacting with ER-α and ER-β, which have been identified on the intestine. ► Both ERα and ERβ agonist could play an important roles in leukocyte -endothelium interaction ► Both ERα and ERβ agonist could influence neutrophil extravasations ► Both ERα and ERβ agonist could improve intestinal perfusion.