Role of FAK in S1P-regulated endothelial permeability

► S1P is an endogenous phospholipid that potently enhances the endothelial barrier. ► Cytoskeletal and junctional complex rearrangement mediate the S1P response. ► S1P stimulates FAK phosphorylation and activation in endothelial cells. ► FAK is integral to cytoskeletal and junctional complex rearrangement induced by S1P.