کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1995038 | 1064949 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ramp acceleration and hydraulic conductivity (Lp) of living capillaries
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Living mesenteric capillaries with either an intact or disrupted glycocalyx were challenged with ramp change in shear stress (ÎÏ). Animals (Rana pipiens) were divided randomly into two experimental groups, and two true capillaries (TC) per animal were investigated. The modified Landis technique was combined with intravital microscopy to view individual TC and assess hydraulic conductivity (Lp), an index of capillary function. Median Lp was 3.2 Ã 10â 7 for control and 11.8 Ã 10â 7 cm sâ 1 cm H2Oâ 1 after mild, brief (1 min) pronase treatment (P < 0.0001). Analysis by stimulus component showed that Lp for untreated capillaries was related negatively to ramp acceleration (R2 = 0.46, P < 0.0001, n = 38) and positively to ÎÏ magnitude (R2 = 0.28, P = 0.0006, n = 38). Disrupting the capillary glycocalyx revealed a positive and previously unknown relationship between ramp acceleration and Lp (R2 = 0.44, P = 0.002, n = 19) plus an upward shift (increased intercept) of the magnitude ÎÏ-Lp relationship compared to abrupt stimulation. These data suggest that bloodstream hemodynamics may impact capillary function. Further, an intact glycocalyx may protect capillaries when blood flow changes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microvascular Research - Volume 79, Issue 2, March 2010, Pages 114-120
Journal: Microvascular Research - Volume 79, Issue 2, March 2010, Pages 114-120
نویسندگان
Donna A. Williams,