کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1995097 1064952 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of a standardized oral fat load on vascular remodelling markers in healthy subjects
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Effects of a standardized oral fat load on vascular remodelling markers in healthy subjects
چکیده انگلیسی

The most adequate way to experimentally reproduce the post-prandial lipemia condition appears to be the administration of a standardized oral fat load (OFL) to fasting patients. We studied the effects of a standardized OFL on markers of vascular remodelling in healthy subjects.We enrolled 286 Caucasians aged ≥ 18 of either sex. The OFL was given after a 12-h fast. Blood samples were drawn before and 3, 6, 9 and 12 h after the fat load. The following parameters were evaluated: body mass index (BMI), blood glucose (BG), systolic blood pressure (SBP), diastolic blood pressure (DBP), lipid profile, nitrites and nitrates, adiponectin (ADP), metalloproteinase-2 (MMP-2) and metalloproteinase-9 (MMP-9).High density lipoprotein-cholesterol (HDL-C) decrease was present in subjects after 6 h. Triglycerides (Tg) change was observed after 6 h. Nitrites/nitrates variation was observed after 6 and 9 h during OFL. Adiponectin level was decreased after 6 and 9 h during OFL. Both MMP-2 and MMP-9 levels were higher after 6 h during OFL.We observed that nitrites/nitrates and ADP significantly decreased and MMP-2 and MMP-9 significantly increased after a standardized OFL. Other studies need to confirm the direct acute effects of post-prandial lipemia on vascular damage.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microvascular Research - Volume 80, Issue 1, July 2010, Pages 110–115
نویسندگان
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