کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1995213 1064957 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reproducibility of a local cooling test to assess microvascular function in human skin
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Reproducibility of a local cooling test to assess microvascular function in human skin
چکیده انگلیسی

ObjectiveIn the present study we aimed to assess the reproducibility of skin microvascular reactivity while fast cooling locally with a custom-designed laser-Doppler flowmetry (LDF) probe.MethodsTwenty-two healthy volunteers underwent local 15 °C cooling on the forearm during 5 (protocol 1, n = 12) or 30 min (protocol 2, n = 10). Skin blood flow was concomitantly assessed using LDF. Measurements were repeated after 30 min (protocol 1) or 7 days (protocols 1 and 2). Data were expressed as cutaneous vascular conductance (CVC) and percentage of baseline (%BL). Within subject coefficients of variation (CV) and intra-class correlation coefficients (ICC) were calculated.ResultsImmediate reproducibility of the 5-min cooling was very good, either expressed as CVC or %BL (CV were 8% and 18%; ICC were 0.85 and 0.78, respectively). However, the 30-min cooling was the most reproducible at 1 week, either as CVC or %BL (CV were 26% and 23%; ICC were 0.86 and 0.75, respectively). Local cooling was well tolerated by all volunteers.ConclusionsWe propose in the present work a reproducible 30-min LDF cooling test. Such a tool could be of great interest to assess microvascular reactivity to local cooling in diseases such as Raynaud's syndrome, and to further evaluate drugs for such diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microvascular Research - Volume 79, Issue 1, January 2010, Pages 34–39
نویسندگان
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