کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1995274 1064960 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Electrokinetic effect of the endothelial glycocalyx layer on two-phase blood flow in small blood vessels
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Electrokinetic effect of the endothelial glycocalyx layer on two-phase blood flow in small blood vessels
چکیده انگلیسی

Blood flow behaves differently at the microvascular level than they do at upper levels of circulating systems. The endothelial glycocalyx layer on the luminal surface of blood vessels plays a significant role in regulating blood flow and blood cell movement in microvascular networks. For instance, previous experimental studies showed that the endothelial glycocalyx layer causes additional resistance to blood flow in small blood vessels. One of the important facts of the endothelial glycocalyx layer is that this layer is highly negatively charged. The question remains: do these electrostatic charges retard blood flow in small blood vessels according to the electroviscous effect? Here, a theoretical model is proposed to investigate the electrochemical effects of the endothelial glycocalyx layer on two-phase non-Newtonian blood flow in small blood vessels. Results show that electrostatic charges on the endothelial glycocalyx layer induce negligible effect to blood flow. Therefore, we can attribute the cause of additional resistance by the endothelial glycocalyx layer mainly to other mechanisms, such as, the glycocalyx constituted proteins acting as a flow barrier.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microvascular Research - Volume 78, Issue 1, June 2009, Pages 14–19
نویسندگان
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