کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1995461 | 1064971 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Vascular leakage induced by exposure to arsenic via increased production of NO, hydroxyl radical and peroxynitrite
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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![عکس صفحه اول مقاله: Vascular leakage induced by exposure to arsenic via increased production of NO, hydroxyl radical and peroxynitrite Vascular leakage induced by exposure to arsenic via increased production of NO, hydroxyl radical and peroxynitrite](/preview/png/1995461.png)
چکیده انگلیسی
Both L-NAME (0.02, 0.1 and 0.5 µmol/site) and DMTU (0.05, 0.2 and 1.2 μmol/site) inhibited the increase in vascular leakage induced by arsenite. However, only high dose (1 μmol/site) of AG significantly attenuated arsenite-induced vascular leakage. In contrast, neither D-NAME (0.02, 0.1 and 0.5 µmol/site) nor AG (0.04 and 0.2 μmol/site) attenuated increased vascular leakage by arsenic. DMTU mixed with L-NAME caused no further inhibition of arsenic-induced vascular leakage by either DMTU or L-NAME. The techniques of India ink and immunostaining were used to demonstrate both vascular labeling and nitrotyrosine staining in tissue treated with arsenic. L-NAME apparently reduced the density of leaky vessels and the levels of peroxynitrite staining induced by arsenite. These results suggest that NO, OHâ and peroxynitrite play a role in increased vascular permeability induced by arsenic exposure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microvascular Research - Volume 75, Issue 3, April 2008, Pages 373-380
Journal: Microvascular Research - Volume 75, Issue 3, April 2008, Pages 373-380
نویسندگان
Shih-Chieh Chen, Wei-Chi Chen,