کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1995619 1541440 2015 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Targeting HER (ERBB) signaling in head and neck cancer: An essential update
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Targeting HER (ERBB) signaling in head and neck cancer: An essential update
چکیده انگلیسی

HNC (head and neck cancer) remains the 6th most common carcinoma worldwide. The suboptimal survival and toxicities observed with conventional approaches warrant exploration of novel therapeutic strategies such as targeted therapies. Although targeting EGFR (epidermal growth factor receptor) with cetuximab demonstrated clinical promise, HER (human epidermal growth factor receptor) or ERBB (erythroblastic leukemia viral oncogene homolog) targeted therapy in HNC has overall been suboptimal to date in clinical settings. Overcoming the resistance as well as identifying new strategies therefore remains a significant challenge. In this review, we will discuss the emerging roles of HER members besides EGFR. A comprehensive “three-dimensional” view of HER signaling pathway from the importance of EGFR nuclear translocation to our maturing concept of receptors' “spatial regulation”, as well as the interdependence and interaction among different HER members will also be addressed to complete an essential update of HER signaling in HNC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Aspects of Medicine - Volume 45, November 2015, Pages 74–86
نویسندگان
, , , ,