کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1995881 | 1541469 | 2010 | 15 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The Warburg effect and mitochondrial stability in cancer cells The Warburg effect and mitochondrial stability in cancer cells](/preview/png/1995881.png)
The last decade has witnessed a renaissance of Otto Warburg’s fundamental hypothesis, which he put forward more than 80 years ago, that mitochondrial malfunction and subsequent stimulation of cellular glucose utilization lead to the development of cancer. Since most tumor cells demonstrate a remarkable resistance to drugs that kill non-malignant cells, the question has arisen whether such resistance might be a consequence of the abnormalities in tumor mitochondria predicted by Warburg. The present review discusses potential mechanisms underlying the upregulation of glycolysis and silencing of mitochondrial activity in cancer cells, and how pharmaceutical intervention in cellular energy metabolism might make tumor cells more susceptible to anti-cancer treatment.
Journal: Molecular Aspects of Medicine - Volume 31, Issue 1, February 2010, Pages 60–74