RNF12 Controls Embryonic Stem Cell Fate and Morphogenesis in Zebrafish Embryos by Targeting Smad7 for Degradation

► RNF12 E3 ubiquitin ligase is a critical positive regulator of TGF-β family signaling ► RNF12 induces polyubiquitination and degradation of Smad7 ► RNF12 controls BMP and activin-induced differentiation responses in ESCs ► RNF12 antagonizes Smad7 function in zebrafish embryos