A Core Chromatin Remodeling Factor Instructs Global Chromatin Signaling through Multivalent Reading of Nucleosome Codes

► MTA1 methylation dictates the chromatin remodeling activity of the NuRD complex ► MTA1 interprets the “nucleosome code” via engaging multivalent chromatin marks ► Methylated and demethylated MTA1 nucleate complexes with opposite functions ► MTA1's methylation status plays an instructive role in the transcriptional outcome