SUMO-Specific Protease 1 Is Critical for Early Lymphoid Development through Regulation of STAT5 Activation

► SENP1 is essential for early T and B cell lymphopoiesis ► SENP1 regulates the SUMOylation status of STAT5 ► SUMOylation of STAT5 blocks its acetylation and subsequent signaling ► SENP1 is required for STAT5 signaling during early T and B cell development