USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development

► Sirt1 interacts with both USP22 and p53 to form a complex ► USP22 is a deubiquitinase of Sirt1 ► USP22 inhibits p53 functions through Sirt1 stabilization ► Targeted usp22 gene mutation leads to mouse embryonic lethality