A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage Signaling to Ubiquitin-Mediated NF-κB Activation

► DNA damage invokes two signaling axes, triggered by ATM and PARP-1, to activate NF-κB ► ATM binds to TRAF6 to induce Ubc13-dependent K63-linked polyUb synthesis ► TRAF6 ubiquitination activates TAK1 and cIAP1-dependent IKKγ monoubiquitination ► IKKγ-monoUb requires both PARP-1 and ATM signals and is essential for IKK activation