Poly (ADP-Ribose) Glycohydrolase Regulates Retinoic Acid Receptor-Mediated Gene Expression

► The catalytic activity of PARG is required for RAR-dependent gene transcription ► PARG accumulates at the promoters of RAR-responsive genes ► KDM4D is PARsylated by PARP-1 in the absence of PARG ► Unparsylable KDM4D compensates for the absence of PARG