کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1997413 1065577 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Paracaspase MALT1 Controls Caspase-8 Activation during Lymphocyte Proliferation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The Paracaspase MALT1 Controls Caspase-8 Activation during Lymphocyte Proliferation
چکیده انگلیسی

SummaryCaspase-8, an initiator caspase involved in lymphocyte apoptosis, is paradoxically required for lymphocyte proliferation. It is not understood how caspase-8 is controlled during antigenic signaling to allow for activation while averting the triggering of apoptosis. Here, we show that caspase-8 undergoes limited activation upon antigenic stimulation, and this activation is dependent on the paracaspase MALT1. The paracaspase domain of MALT1, in a protease-independent manner, induces caspase-8 activation through direct association. MALT1 diminishes the activation of apoptotic effector caspases, but it does not alter the activity of caspase-8 toward c-FLIPL, which is required for antigenic signaling. Mutants of MALT1 that fail to activate caspase-8 and permit c-FLIPL cleavage cannot facilitate NF-κB activation or IL-2 induction. Our results reveal a mechanism that utilizes a protease potentially deadly to the cell for proliferative signaling and demonstrate a functional connection between the caspase and paracaspase families to enable nonapoptotic processes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 31, Issue 3, 8 August 2008, Pages 415–421
نویسندگان
, , , ,