کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1997859 1065622 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differential Modification of Ras Proteins by Ubiquitination
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Differential Modification of Ras Proteins by Ubiquitination
چکیده انگلیسی

SummaryRas proteins are essential components of signal transduction pathways that control cell proliferation, differentiation, and survival. It is well recognized that the functional versatility of Ras proteins is accomplished through their differential compartmentalization, but the mechanisms that control their spatial segregation are not fully understood. Here we show that HRas is subject to ubiquitin conjugation, whereas KRas is refractory to this modification. The membrane-anchoring domain of HRas is necessary and sufficient to direct the mono- and diubiquitination of HRas. Ubiquitin attachment to HRas stabilizes its association with endosomes and modulates its ability to activate the Raf/MAPK signaling pathway. Therefore, differential ubiquitination of Ras proteins may control their location-specific signaling activities.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 21, Issue 5, 3 March 2006, Pages 679–687
نویسندگان
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