کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1998144 1065650 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human Telomeres Have Different Overhang Sizes at Leading versus Lagging Strands
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Human Telomeres Have Different Overhang Sizes at Leading versus Lagging Strands
چکیده انگلیسی

SummaryG-rich 3′ telomeric overhangs are required both for forming the distinct telomere structures to protect chromosome ends and for extending telomeres by telomerase. However, little is known about the molecular mechanisms generating telomere overhangs in human cells. We show here that cultured normal human diploid cells have longer G overhangs at telomeres generated by lagging-strand synthesis than by leading-strand synthesis. We also demonstrate that telomerase expression results in elongated overhangs at the leading daughter telomeres. Thus, the overhangs at the leading and lagging daughter telomeres are generated differently in human cells, and telomerase may preferentially affect overhangs generated at the telomeres produced by leading-strand synthesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 21, Issue 3, 3 February 2006, Pages 427–435
نویسندگان
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