کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1998839 1065821 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of a single dose of N-carbamylglutamate on the rate of ureagenesis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Effects of a single dose of N-carbamylglutamate on the rate of ureagenesis
چکیده انگلیسی
We studied the effect on ureagenesis of a single dose of N-carbamylglutamate (NCG) in healthy young adults who received a constant infusion (300 min) of NaH13CO3. Isotope ratio-mass spectrometry was used to measure the appearance of label in [13C]urea. At 90 min after initiating the H13CO3- infusion each subject took a single dose of NCG (50 mg/kg). In 5/6 studies the administration of NCG increased the formation of [13C]urea. Treatment with NCG significantly diminished the concentration of blood alanine, but not that of glutamine or arginine. The blood glucose concentration was unaffected by NCG administration. No untoward side effects were observed. The data indicate that treatment with NCG stimulates ureagenesis and could be useful in clinical settings of acute hyperammonemia of various etiologies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Genetics and Metabolism - Volume 98, Issue 4, December 2009, Pages 325-330
نویسندگان
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