کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1999140 1065842 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels
چکیده انگلیسی

Individuals homozygous for the thermolabile variant (677TT) of methylenetetrahydrofolate reductase exhibit reduced folate status as evidenced by a drop in the biomarker red cell folate (RCF) compared to those who carry at least one 677C allele. We now report that a different polymorphism in the same enzyme, namely 1298A > C, is associated with increased RCF levels. Thus, these two common polymorphisms change a metabolic phenotype in opposite directions suggesting that their cancer protective associations are by different mechanisms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Genetics and Metabolism - Volume 88, Issue 3, July 2006, Pages 290–294
نویسندگان
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