Contribution of either YY1 or BclXL-induced inhibition by the NO-donor DETANONOate in the reversal of drug resistance, both in vitro and in vivo. YY1 and BclXL are overexpressed in prostate cancer

► We analyzed the chemosensitizing activity and mechanism of action of nitric oxide. ► We identified at YY1 and BclXL in PCa that regulate resistance and are inhibited by NO. ► The combination of NO and CDDP was an effective therapy in tumor regression in vivo.