کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2000987 1066016 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewThe evolutionary functions of cardiac NOS/NO in vertebrates tracked by fish and amphibian paradigms
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
ReviewThe evolutionary functions of cardiac NOS/NO in vertebrates tracked by fish and amphibian paradigms
چکیده انگلیسی

During early ectotherm vertebrate evolution the heart was redesigned as a high pressure pump adapted to perfuse larger body sizes. To compensate the consequent higher organ complexity and heterogeneity (ventricular myoarchitecture and blood supply), conceivably the three principal cardiac cell components, the endocardium, the contractile myocardium and the epicardium recruited and diversified the cardiac NOS system for functioning not only as a major modulator, but also as a spatio-temporal integrator of heart function. In the context of NOS isoform evolution, we will use fish and amphibian paradigms to illustrate major aspects of cardiac spatial and temporal integration achieved by the NOS/NO systems. This may reveal a primordial cardiac NOS/NO function, allocating it in a wider biological framework than so far envisioned.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nitric Oxide - Volume 25, Issue 1, 30 June 2011, Pages 1-10
نویسندگان
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