Synthesis, antibacterial and antifungal activities of some N-nitroso-2,6-diarylpiperidin-4-one semicarbazones and QSAR analysis

A series of N-nitroso-2,6-diarylpiperidin-4-one semicarbazones and thiosemicarbazones were synthesized, characterized by IR, NMR and elemental analysis. All the compounds were screened for their antibacterial activity against Gram-positive bacteria Bacillus subtilis, Staphylococcus aureus and Gram-negative bacteria Escherichia coli and fungi Candida albicans. These compounds have showed moderate and very good antibacterial activity. Quantitative Structure Activity Relationship (QSAR) analysis was performed for these compounds by the application of Semiempirical calculations and molecular modeling. Different log P values were also evaluated to further the analysis.