کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
20017 43153 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Insights into copper effect on Proteus hauseri through proteomic and metabolic analyses
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Insights into copper effect on Proteus hauseri through proteomic and metabolic analyses
چکیده انگلیسی

This is the first-attempt to use liquid chromatography coupled with tandem mass (LC-MS-MS) in deciphering the effects of copper ion on Proteus hauseri. Total 941 proteins in copper-addition (+Cu) group and 898 proteins in non-copper-addition (−Cu) group were found, which containing 221 and 178 differential proteins in +Cu and −Cu group, respectively. Differential proteins in both groups were defined into 14 groups by their functional classification which transport/membrane function proteins were the major different part between the two groups, which took 19.5% and 7.7%, respectively. The result of BioCyc and KEGG analyses on metabolic pathway indicated that copper could interrupted the pathway of chemotaxis CheY and inhibited the swarming of P. hauseri, which provided a potential in controlling the pathogenicity of this strain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Bioscience and Bioengineering - Volume 121, Issue 2, February 2016, Pages 178–185
نویسندگان
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