Hyperbranched polyester polyacids and their binary systems with surfactants for doxorubicin encapsulation

• Binary systems based on modified Boltorn H and a surfactant for doxorubicin encapsulation.
• The effect of Boltorn H functionalization degree on doxorubicin encapsulation degree.
• The effect of polymer/surfactant concentration ratio on doxorubicin encapsulation degree.

Doxorubicin fixation by hyperbranched polyester polyol Boltorn H acid derivatives and their binary systems in the presence of a surfactant (Brij-35, Triton X-100) was investigated. Doxorubicin fixation degree nonlinearly depends on the number of acid groups in the polyester polyacid. Polyacid/surfactant binary systems fix up to 60% of doxorubicin from the solution.

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