کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
201071 460532 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Continuous-flow microfluidic method for octanol-water partition coefficient measurement
ترجمه فارسی عنوان
روش میکرو فلوئیدیک مداوم جریان برای اندازه گیری ضریب پارتیشن آب اکتانول
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
چکیده انگلیسی

To determine the octanol–water partition coefficient (log Kow or log D), a microfluidic method is developed to reduce time and coast of analyze. A double Y serpentine microfluidic chip is fabricated used soft lithography facilities. To generate a biphasic parallel flow, hydrophilic microchannels walls are generated by oxygen plasma treatment. Epifluorescence microscopy is used to measure the intensity of fluorescence molecules in microchannel. Using microfluidic parallel diluter this intensity show a strong linear correlation with molecule concentration in solution. The equilibrium between phases is reached in less than 5 s. To validate this microsystem, we have determined the log D of fluorescein natrium molecule. The obtained results compare well with previous measurements using traditional shake-flask or microfluidic drops flow methods, with a relative difference to the literature less than 3%. Rapid microfluidic partition coefficient determination is useful for studying liquid–liquid partition of organic pollutant.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fluid Phase Equilibria - Volume 380, 25 October 2014, Pages 116–120
نویسندگان
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