Ameliorative effects of baicalein in MPTP-induced mouse model of Parkinson's disease: A microarray study

• Baicalein significantly attenuates MPTP-induced motor behavioral deficits.
• Baicalein promotes biological processes of neurogenesis and neuroblast proliferation.
• Baicalein promotes neurotrophin signaling pathway.
• Baicalein inhibits dopamine metabolism process.
• The regulation of LIMK1, SNCA and GLRA1 by baicalein might play central roles in Parkinson's disease.

Baicalein, a flavonoid from Scutellaria baicalensis Georgi, has been shown to possess neuroprotective properties. The purpose of this study was to explore the effects of baicalein on motor behavioral deficits and gene expression in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice model of Parkinson's disease (PD). The behavioral results showed that baicalein significantly improves the abnormal behaviors in MPTP-induced mice model of PD, as manifested by shortening the total time for climbing down the pole, prolonging the latent periods of rotarod, and increasing the vertical movements. Using cDNA microarray and subsequent bioinformatic analyses, it was found that baicalein significantly promotes the biological processes including neurogenesis, neuroblast proliferation, neurotrophin signaling pathway, walking and locomotor behaviors, and inhibits dopamine metabolic process through regulation of gene expressions. Based on analysis of gene co-expression networks, the results indicated that the regulation of genes such as LIMK1, SNCA and GLRA1 by baicalein might play central roles in the network. Our results provide experimental evidence for the potential use of baicalein in the treatment of PD, and revealed gene expression profiles, biological processes and pathways influenced by baicalein in MPTP-treated mice.

Figure optionsDownload as PowerPoint slide