Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: Implication for osteoarthritis therapy

► SMT produces antinociception in MIA-induced osteoarthritis in rats. ► SMT attenuates cartilage degeneration in MIA-induced osteoarthritis in rats ► SMT has excellent potential as a therapeutic modality for treatment of osteoarthritis.