Paradoxical effects of apolipoprotein E on cognitive function and clinical progression in mice with experimental autoimmune encephalomyelitis

► Apoe−/− mice show decreased CD4 + cell invasion following EAE. ► Apoe−/− mice also show less spinal cord demyelination at 17 days following EAE. ► EAE-challenged Apoe−/− mice show reduced exploratory activity. ► EAE-challenged Apoe−/− mice show reduced rotorod performance. ► EAE-challenged Apoe−/− mice show impaired contextual fear conditioning.