کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2013565 1067122 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Testosterone reduces cumulative burying in female Wistar rats with minimal participation of estradiol
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Testosterone reduces cumulative burying in female Wistar rats with minimal participation of estradiol
چکیده انگلیسی

Testosterone exerts anxiolytic effects, but the participation of its aromatase metabolic product estradiol is controversial. Therefore, we used the defensive burying paradigm in female Wistar rats to explore testosterone's (1.0 mg/rat, s.c.) interactions with picrotoxin (a noncompetitive γ-aminobutyric acid-A receptor [GABAA] antagonist; 1.0 mg/kg, i.p.), formestane (an aromatase inhibitor; 3.0 mg/rat, s.c.), and tamoxifen (an estrogen receptor-β antagonist; 1.0 mg/kg, s.c.). Serum levels of testosterone, estradiol, and progesterone were determined in the same rats. Burying latency and locomotion did not significantly change. Systemic testosterone administration enhanced serum testosterone and estradiol levels and reduced defensive burying. This reduction in total burying was blocked by pretreatment with picrotoxin and tamoxifen, but not formestane. We conclude that testosterone produced anxiolytic-like effects in female rats that were mediated by actions at the GABAA receptor, with participation of the estradiol receptor-β, rather than estradiol aromatization.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 93, Issue 4, October 2009, Pages 406–412
نویسندگان
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