کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2013672 | 1067126 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antidepressant-like effects of paroxetine are produced by lower doses than those which produce nausea
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Paroxetine is prescribed to treat depression, but it also produces nausea. The potential of animal models to detect nauseating, antidepressant-like, and rewarding/aversive effects of paroxetine were assessed. In Experiments 1 (spaced conditioning trials) and 3 (massed conditioning trials), a dose of 30Â mg/kg, but not lower doses (3 and 10Â mg/kg) of paroxetine produced conditioned gaping reactions (reflective of nausea) in the Taste Reactivity (TR) test. In Experiment 2, when administered 23.5, 5 and 1Â h prior to a 5Â min forced swim test (FST) a dose as low as 3Â mg/kg of paroxetine increased swimming and decreased immobility (reflective of antidepression) compared to controls. In Experiment 3, neither 10 nor 30Â mg/kg of paroxetine produced a conditioned floor preference/aversion, but both doses decreased activity during conditioning trials. These results suggest that paroxetine produced an antidepressant-like effect at a lower dose (3Â mg/kg) than that necessary to produce nausea (30Â mg/kg). The TR test may be beneficial for assessing the side effect of nausea in preclinical tests of new compounds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 93, Issue 2, August 2009, Pages 190-195
Journal: Pharmacology Biochemistry and Behavior - Volume 93, Issue 2, August 2009, Pages 190-195
نویسندگان
Katharine J. Tuerke, Francesco Leri, Linda A. Parker,