کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2013731 1067129 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neurobehavioral effects of environmental enrichment and drug abuse vulnerability
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Neurobehavioral effects of environmental enrichment and drug abuse vulnerability
چکیده انگلیسی

Environmental enrichment during development produces a host of neurobehavioral effects in preclinical models. Early work demonstrated that enrichment enhances learning of a variety of behavioral tasks in rats and these changes are associated with neural changes in various cortical regions. In addition to promoting superior learning, more recent evidence suggests that environmental enrichment also has a protective effect in reducing drug abuse vulnerability. The current review describes some of the most important environment-dependent neural changes in reward-relevant brain structures and summarizes some of the key findings from the extensive literature showing how enrichment decreases the impact of drugs of abuse. Some critical neural mechanisms that may mediate the behavioral changes are postulated, along with some notes of caution about the limitations of the work cited.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 92, Issue 3, May 2009, Pages 377–382
نویسندگان
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