کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2013736 1067129 2009 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of pretest manipulation on elevated plus-maze behavior in adolescent and adult male and female Sprague–Dawley rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Effects of pretest manipulation on elevated plus-maze behavior in adolescent and adult male and female Sprague–Dawley rats
چکیده انگلیسی

The elevated plus-maze (EPM) is vulnerable to variations in pretest circumstances when testing adult rodents. Because of an increasing interest in adolescence, the present experiments examined the impact of pretest manipulations on anxiety levels in the EPM among adolescent and adult Sprague–Dawley rats of both sexes. In Exp. 1, animals removed from their home cage and immediately placed on the EPM were compared to rats tested following 30 min of social isolation, or following 30-min exposure to a novel context. These pretest manipulations only modestly decreased anxiety levels at both ages. In Exp. 2, more varied pretest conditions were examined: testing directly from the home cage; testing following 30 min of social isolation in a novel environment; or a large saline injection and rehousing 18 h prior to a 30-min period of social isolation in a novelty situation before testing. In adults, anxiety levels decreased linearly as pretest perturbation increased, whereas adolescents showed comparable levels of anxiety with both the moderate and large perturbations. As a result, observed age differences in anxiety differed as a function of pretest circumstances. Therefore, caution is urged when using the EPM for across-age comparisons of anxiolytic and anxiogenic effects of pharmacological or other manipulations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 92, Issue 3, May 2009, Pages 413–423
نویسندگان
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