کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2014001 | 1067139 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Discrimination and avoidance learning in adult mice following developmental exposure to diisopropylfluorophosphate Discrimination and avoidance learning in adult mice following developmental exposure to diisopropylfluorophosphate](/preview/png/2014001.png)
Exposure to acetylcholinesterase inhibitors during development was shown in the past to induce sex-dependent changes in locomotion and specific cognitive and emotional tests in rodents. Adult mice that had been treated with 0.5 mg/kg diisopropylfluorphosphate (DFP), on post-natal days 14–20 were tested on active avoidance and a set-shifting task. DFP pre-treatment did not affect the active avoidance task, but impaired performance on the extra-dimensional shift task. DFP-treated females showed more general deficits in the acquisition of simple discrimination, intra-dimensional shift, extra-dimensional shift and reversal learning. These data suggest that pre-weanling exposure to cholinesterase inhibitors may have long-term consequences on attentional capabilities.
Journal: Pharmacology Biochemistry and Behavior - Volume 88, Issue 4, February 2008, Pages 438–445